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My husband and I had the opportunity to visit Portland Oregon recently. This was his first time to Oregon, and my first time to Portland. We stayed at the beautiful River Place hotel. I highly recommend staying out this hotel. The service is incredible, they have hot chocolate, cider and appetizers in the lobby, and the view is incredible.
My biggest tip would be to call in advance and ask for a river view room. We did not do this, so our view was of the Valet parking lot. I was very sad not to have the river view. The hosts were very helpful, though and upgrade us to a nicer room, since a river view was not available.
The rooms were very clean, the service was fantastic (they even brought complimentary chocolates and water to our room), and are stay was very nice. The hotel is family friendly and open to children, but I enjoyed it being just my husband and I. It is a very quiet hotel and I might have been a little uncomfortable with my kids.
There is a in hotel restaurant that I recommend enjoying at least once for breakfast. The food was delicious, but I enjoyed it most for the sunrise and beautiful marina view. 
Our favorite part of the hotel was that they had complimentary bikes that their guests could borrow. Portland is very bike friendly so you can get many places by bike. We borrowed their bikes two different times. First to get breakfast and see the city and second to ride across the bridge and see the other side of the city. It was very cold (we had to stop to by gloves and hats) but the experience was incredible, view was beautiful and we had so much fun.

 For more information about the River Place Hotel, or to book a room you can visit them at: River Place Hotel.